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KMID : 0380420220460030164
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Journal of Prventive Veterinary Medicine
2022 Volume.46 No. 3 p.164 ~ p.169
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Virucidal efficacy of gaseous chlorine dioxide against surface-dried Adenovirus and Herpesvirus
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Tran Xuan Ngoc Huy
Trang Thi Nguyen
Alisha Wehdnesday Bernardo Reyes
Kim Hee-Jin
Min Won-Gi
Lee Hu-Jang
Kim Suk
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Abstract
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Chlorine dioxide (ClO2) has recently emerged as an ideal disinfectant and has shown a wide range of antimicrobial activities in various pathogenic microorganisms. In this study, the virucidal effect of ClO2 at low concentration (0.02 ppm) and higher concentration (0.06 ? 0.09 ppm) against Adenovirus and Herpesvirus was evaluated based on the NF T 72-281 and ASTM 1053-11 standard methods at different exposure times. The virus suspension was dried onto the carrier and then exposed to gaseous ClO2 (gClO2) at 22 ± 2?C. For Adenovirus, exposure at a low concentration of ClO2 at the middle height resulted in the average log10 reduction of 0.95, 2.65, and 5.30 after 1, 3, and 6 h post-exposure (pe), respectively. Moreover, more than 4-log10 reduction was achieved at 4 and 6 h pe with higher concentrations of ClO2. On the other hand, the antiviral activity of gClO2 at the middle height was also effective against Herpesvirus. In particular, at 1 h pe, a less than 4-log10 reduction was observed at all examined concentrations of ClO2, whereas exposure for 3 and 6 h (with low concentration) or 2 h (with higher concentration) inactivated completely viruses attached to the carrier. These results suggested that ClO2 fumigation is a potential alternative method for disinfecting healthcare facilities, high-containment laboratories, and households with a safe concentration for human health.
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KEYWORD
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Adenovirus, Herpesvirus, Chlorine dioxide, disinfection, gas fumigation
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